Intellectual Disability and Developmental Risk: Promoting Intervention to Improve Child and Family Well‐Being          下载免费PDF全文

Keith A. Crnic  Cameron L. Neece  Laura Lee McIntyre  Jan Blacher  Bruce L. Baker 《Child development》2017,88(2):436-445

Initial intervention processes for children with intellectual disabilities (IDs) largely focused on direct efforts to impact core cognitive and academic deficits associated with the diagnosis. Recent research on risk processes in families of children with ID, however, has influenced new developmental system approaches to early intervention. Recent risk and resilience processes are reviewed that connect stress, family process, and the high rates of behavioral problems in children with ID that have substantial influence on child and family outcomes. These models are linked to emerging evidence‐based intervention processes that focus on strategic parent skill training and mindfulness interventions that reduce parental stress and create indirect benefits for children's behavioral competencies. A family‐focused developmental systems approach (M. J. Guralnick, 2011) is emphasized.  相似文献   

Effects of vanadate supplementation on high fat-diet and diabetes-induced metabolic changes in liver     

Subbiah Pugazhenthi  Joseph F. Angel  Ramji L. Khandelwal 《Indian journal of clinical biochemistry : IJCB》1996,11(2):108-114

Normal and streptozotocin-induced diabetic rats were fed the control high starch-diet or a high fatdiet supplemented with or without sodium orthovanadate (1.5 mg/g diet) for six weeks. Plasma glucose, insulin and triacylglycerol levels and the activities of hepatic glycogen synthase, phosphorylase, glucose-6-phosphate dehydrogenase, malic enzyme, and ATP-citrate lyase were measured in these eight groups of rats. The high fat-diet increased the levels of insulin (P<0.05) and triacylglycerol (P<0.01) in plasma and decreased the activities (P<0.001) of phosphorylase (active from and total) and the lipogenic enzymes. Vanadate supplementation led to significant (P<0.001) decreases in the elevated insulin and triacylglycerol levels whereas the enzyme activities remained unaffected. Diabetes and fat diet in combination caused 3.7-fold increases in plasma glucose and triacylglycerol levels and vanadate decreased them by 58% and 74% respectively. Vanadate improved the activities of hepatic glycogen metabolizing and lipogenic enzymes in diabetic rats when they were fed on control starch-diet but not with high fat-diet. This study shows that vanadate normalizes hyperinsulinemia and hypertriglyceridemia but not the defective hepatic glycogen metabolism in high fat-fed rats.  相似文献   

Raised serum homocysteine levels in patients of coronary artery disease and the effect of vitamin B12 and folate on its concentration     

R Abraham  M Joseph John  R Calton  J Dhanoa 《Indian journal of clinical biochemistry : IJCB》2006,21(1):95-100

Homocysteine(Hcy) has been implicated as a novel risk factor of Coronary Artery Disease (CAD) among Asian Indians, but many studies done in India failed to reveal any direct correlation. It has also been reported that Folic acid and Vitamin B12 levels inversely affect serum levels of homocysteine. In this study, we looked at the levels of homocysteine among patients with CAD. The effect of Vitamin B12, Folate and other risk factors on homocysteine levels were also evaluated. Mean homocysteine levels in cases (22.81±13.9, n=70) were significantly higher (p=<0.001) than the controls (7.77±7.3, n=70). However no statistically significant correlation could be deduced between homocysteine Vitamin B12, and Folate. Cumulative analysis have indicated an increase in homocysteine levels among patients with CAD with every additional risk factor.  相似文献   

Muscular marxism and the Chicago counter‐olympics of 1932     

William J. Baker 《国际体育史杂志》2013,30(3):397-410

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The University Supervisor of Student Teachers     

Joseph C. English 《College Teaching》2013,61(2):157-158

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Qualitative studies in education at the beginning of the twenty‐first century     

James Joseph Scheurich  M. Carolyn Clark Co‐Editors 《International journal of qualitative studies in education》2013,26(4)

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Guest editor's introduction     

James Joseph Scheurich 《教育政策杂志》2013,28(4)

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A response to ‘Agenda for reform: a critical appraisal‘     

Joseph Murphy 《教育政策杂志》2013,28(2)

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Communicative Practices in Workplaces and the Professions: Cultural Perspectives on the Regulation of Discourse and Organizations     

Joseph A. Dawson 《Technical Communication Quarterly》2013,22(2):216-219

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Guidance in the Jewish School     

Joseph Kaminetsky 《Journal of Jewish Education》2013,79(3):197-199

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